TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataKi: 0.260nMAssay Description:Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3...More data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataKi: 0.840nMAssay Description:Agonist activity at human MC1R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataKi: 1.5nMAssay Description:Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3...More data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3...More data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataKi: 5nMAssay Description:Inhibition of recombinant HDAC3 (unknown origin)/NCOR2 (unknown origin) using acetyl-Lys(Ac)-AMC as substrate preincubated for up to 3 hrs followed b...More data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataKi: 13nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC3 (unknown origin)/N-terminal GST-tagged NCoR2 (unknown origin) assessed as inhibition constant (...More data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataKi: 23.1nMAssay Description:Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3...More data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataKi: 24nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC3 (unknown origin)/N-terminal GST-tagged NCoR2 (unknown origin) assessed as inhibition constant o...More data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataKi: 24.9nMAssay Description:Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3...More data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataKi: 25nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC3 (unknown origin)/N-terminal GST-tagged NCoR2 (unknown origin) assessed as equilibrium inhibitio...More data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataKi: 27nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC3 (unknown origin)/N-terminal GST-tagged NCoR2 (unknown origin) assessed as apparent inhibition c...More data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataKi: 37nMAssay Description:Competitive inhibition of HDAC3/NCoR2 using Ac-Lys(Ac)-AMC as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataKi: 39nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC3 (unknown origin)/N-terminal GST-tagged NCoR2 (unknown origin) assessed as inhibition constant (...More data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataKi: 306nMAssay Description:Displacement of [125I]-NDP-MSH from human MC1R expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataKi: 700nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC3 (unknown origin)/N-terminal GST-tagged NCoR2 (unknown origin) assessed as equilibrium inhibitio...More data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataKi: 800nMAssay Description:Inhibition of human C-terminal His-tagged HDAC3 (1 to 428 residues)/human N-terminal GST-tagged NcoR2 (395 to 489 residues) expressed in sf9 cells us...More data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataKi: 3.20E+3nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC3 (unknown origin)/N-terminal GST-tagged NCoR2 (unknown origin) assessed as equilibrium inhibitio...More data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataKi: >4.30E+4nMAssay Description:Inhibition of human HDAC3/NcoR2 using p53 residues 379-382 (RHKKAc) as substrate measured after 2 hrs by Cheng-Prusoff analysisMore data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataKi: >7.50E+4nMAssay Description:Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3...More data for this Ligand-Target Pair